Pearl River Laboratories (PRL) provides a wide range of bioconjugation services from Discovery through Process Development and Technical Transfer to a CMO for bioconjugates including ADCs, Vaccine conjugates, Oligonucleotide conjugates, etc.

Discovery

• Conventional (Cys, Lys, etc.) & Site-specific (Cys mutant, unnatural amino acids, enzyme-based, etc.) conjugations for ADCs

• Conjugation of polysaccharides

• Conjugation of Oligonucleotides

• Purification using SEC, HIC, IEX, Mixed mode, etc.

• Purification/buffer exchange using TFF

• Full Characterization

GLP Toxicology

• Optimization of conjugation & purification processes for desired attributes

• Building DOE models

• Full Characterization & Release

• Comprehensive report

Transfer to CMO:

• Provide detailed technical transfer protocol

• GLP batch record provided

• Oversee demo runs

Coordinate GMP Manufacture at CMO

• Batch record review

• Person in Plant to oversee production

• Address issues that arise

• Provide regulatory strategy and guidance